WebSep 23, 2024 · However, SOX2 is a transcription factor, which makes direct targeting difficult. Thus, MLN4924 appears to be a promising SOX2-targeting agent via SOX2 depletion at the transcription level by inactivation of the FBXW2–MSX2 axis to abrogate cancer stem cells and to overcome drug resistance, 2 major causes of cancer therapeutic … WebSox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly …

The Sox2 transcription factor binds RNA Nature

WebFinally, while most SPFs induce TET-dependent active DNA demethylation, SOX2 binding leads to passive demethylation, an activity enhanced by the co-binding of OCT4. This finding suggests that... WebApr 10, 2024 · The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this … stiff creaky neck

SOX2 SRY-box transcription factor 2 [ (human)] - National Center …

WebApr 14, 2024 · SOX2 can bind directly to ES2 lncRNA with high affinity through its DNA-binding HMG domain [144]. Numerous studies have reported aberrant expression of SOX2 … WebDownloadable! Certain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor … WebMar 2, 2024 · INTRODUCTION. Essential cellular processes such as replication, recombination, and DNA repair occur alongside transcription on DNA. During transcription, RNA polymerase II (RNAPII) pauses at discrete sites, which in some instances is required for proper regulation of gene expression (1, 2).Prolonged pausing and/or stalling of the … stiff cowboy jeans