WebSTAT蛋白家族有7个成员：STAT1、STAT2、STAT3、STAT4、STAT5α、STAT5β和STAT6。 它们可被细胞中的一系列信号蛋白激活，如细胞因子、生长因子、与细胞表面特定受体结合的激素等。 STAT蛋白激活磷酸化后形成同源或异源二聚体，迁至胞核并参与细胞生理或病理过程，包括增殖、分化、凋亡、血管生成 [ 10] ，以及细胞转变、癌形成等 [ 11] … Web10. máj 2024 · 拓扑异构酶II结合蛋白1（DNA topoisomerase II binding protein 1, TOPBP1）是促进ATR信号激活的关键蛋白之一，其一般通过BRCT结构域（BRCA1 C …
人源DNA拓扑异构酶Ⅱβ结合蛋白1(TopBP1)N端结构域的结构生物 …
Web27. máj 2024 · TOPBP1含有多组成对出现的BRCT（BRCA1 C-terminal）结构域，它们负责识别不同磷酸化形式的配体蛋白，决定了TOPBP1在复制起始或复制压力应答中的特异性工 … horning\\u0027s bike shop ephrata pa
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http://www.ebiotrade.com/newsf/2012-4/2012424143821197.htm Webbai等 2014年证实细胞蛋白topbp1进入细胞核也仅需要kpnb1蛋白识别topbp1蛋白中由单簇碱性氨基酸组成的nls (1496 rkrk 1499)。本研究同样发现携带经典双重nls (247 kkgkkvifdkieekirr 263)的ndv m蛋白入核只需要结合kpnb1蛋白，而不需要kpna1蛋白的参与。 … DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein binding partner of DNA topoisomerase-IIβ by a yeast 2-hybrid screen, giving it its name. TOPBP1 is involved in a variety of nuclear specific … Zobraziť viac BRCT domains The TOPBP1 gene encodes a scaffold protein which facilitates interactions between different proteins at specific times and locations. It accomplishes these interactions with … Zobraziť viac • DNA damage repair • Ataxia-telangiectasia mutated and RAD3-related (ATR) • BRCA1 • DNA replication Zobraziť viac DNA damage repair TOPBP1 was first identified as a DNA damage protein through its association with BRCA1, which is a protein heavily implicated in … Zobraziť viac Cancer Changes in TOPBP1 gene expression are associated with breast cancer, glioblastoma, non-small cell lung cancer, and Zobraziť viac • Yamane K, Tsuruo T (September 1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA". Oncogene. 18 … Zobraziť viac horning\\u0027s discount grocery